A recent study conducted by researchers at Edith Cowan University in Australia has found a potential genetic connection between Alzheimer’s disease and several coronary artery disease-related disorders and lipids such as cholesterol. Previous research has already established a link between Alzheimer’s disease and cardiovascular disease, with studies showing that heart conditions like high blood pressure, dyslipidemia, coronary artery disease, and atrial fibrillation can increase the risk of developing dementia. A study published in 2018 also found common genetics between coronary artery disease and Alzheimer’s disease.
The researchers focused on seven traits of coronary artery disease and 13 different lipids associated with the condition. They found a notable genetic connection between all seven coronary artery disease traits assessed, as well as triglycerides. In addition, there was a genetic overlap between Alzheimer’s disease and three lipid measurements — high-density lipoproteins (HDLs), low-density lipoproteins (LDLs), and total cholesterol. Identifying genome-wide significant genes shared across Alzheimer’s disease, lipids, and coronary artery disease traits could potentially improve our understanding of the biological mechanisms underlying these conditions.
While the study sheds light on potential genetic links between Alzheimer’s disease and coronary artery disease, more research is needed to fully understand the mechanisms at play. It is important to note that the identified genes are not yet fully understood in terms of their functions and their specific connections to these diseases. Further genetic studies are necessary to delve deeper into the genetic underpinnings of Alzheimer’s disease and coronary artery disease to identify potential therapeutic targets for both conditions.
Experts caution that while the study provides valuable insights into the genetic overlap between Alzheimer’s disease and coronary artery disease, it is just the beginning of a larger research effort. The shared genes of interest identified in the study may provide clues into common biological pathways between the two diseases, potentially leading to new treatment methods or targets. It is crucial to conduct further research to understand how these genes are related and the mechanisms involved in the development of Alzheimer’s disease and coronary artery disease.
Overall, the study highlights the importance of considering brain health in relation to heart health, as individuals with cardiovascular disease are at an increased risk of developing Alzheimer’s disease and other cognitive decline conditions. The research reinforces the need for regular discussions about brain health, similar to those about heart health, in clinical interactions with patients. Moving forward, further investigation is needed to advance our understanding of the common mechanisms and pathways that may link coronary artery disease, lipids, and Alzheimer’s disease.
