Recent research has identified 17 genetic variants associated with Alzheimer’s disease in five genomic regions. These findings include data from ethnic groups that have been historically underrepresented in genetic studies on Alzheimer’s. While the exact cause of Alzheimer’s disease is still unknown, it is believed to be a combination of genetic factors, age-related brain changes, and environmental and lifestyle factors. Understanding the genetic factors that influence the risk for Alzheimer’s disease can lead to the development of new therapeutic approaches.
The study utilized whole genome sequencing data from the Alzheimer’s Disease Sequencing Project, which provided information on more than 95 million genetic variants from individuals with and without Alzheimer’s disease. By analyzing this data, researchers identified 17 significant variants associated with Alzheimer’s disease in five genomic regions. One of the notable variants was the lysine acetyltransferase 8 (KAT8) variant, which has been linked to cerebral development and may play a role in Alzheimer’s disease-related dementias and Parkinson’s disease.
The study’s access to genetic variant data from diverse ethnicities, including Black/African-American and Hispanic/Latino populations, is significant as these groups have been historically underrepresented in genetic studies on Alzheimer’s disease. By including a diverse range of participants, the researchers aim to gain a more comprehensive understanding of the genetic factors influencing Alzheimer’s disease risk across different populations. This research has been described as a major advance that brings science-based interventions closer to a breakthrough treatment for Alzheimer’s disease.
Dr. Karen D. Sullivan, a neuropsychologist, emphasized the importance of extending the study’s findings to larger sample sizes and linking the genetic variants to their specific cognitive and behavioral changes in individuals with Alzheimer’s disease. While the research represents a significant step forward in understanding the genetics of Alzheimer’s disease, further studies are needed to fully understand the impact of these genetic variants on the development and progression of the disease. Ultimately, the goal is to develop more effective treatments for Alzheimer’s disease and alleviate the significant burden it places on healthcare systems and individuals affected by the condition.
