Christina Applegate has been candid about her struggles with multiple sclerosis (MS) since revealing her diagnosis in 2021. In an emotional episode of “This Life of Mine with James Corden” in August 2024, she recounted the day she received the news about her 30 brain lesions. Despite passing the three-year anniversary of her diagnosis, Applegate still struggles to fully accept her condition, as she expressed on her podcast “MeSsy.” She described her MS symptoms, including intense pain, tingling, and balance issues, revealing that she was in a relapse in April 2024.
In March 2024, Applegate spoke on “Armchair Expert” with Dax Shepard about her debilitating MS symptoms, including issues with mobility and cognitive functions. She called MS the worst thing that has ever happened to her and expressed anger and frustration about living with the disease. Despite her previous battles with breast cancer and preventative surgeries, Applegate finds no solace in her MS diagnosis. She opened up about her struggles on a more public platform in an interview with Robin Roberts on ABC News, revealing how challenging it is to share her experience while living with excruciating pain.
To cope with her MS diagnosis, Applegate announced a new podcast called “MeSsy” with Jamie-Lynn Sigler, who also lives with MS. In March 2024, she shared updates on her symptoms during an interview with People. Applegate candidly discussed the challenges she faced, including weight fluctuations, incontinence, and the intense pain she experiences daily. Despite the difficulties, she remains committed to fighting for her daughter and finding joy in her life. She joked about the struggles she faces, including wearing diapers, as a way to navigate the harsh realities of living with MS.
At the 2024 Emmy Awards in January, Applegate received an emotional response from the audience, but she used humor to deflect the seriousness of her condition, making jokes about her disability. She received support and appreciation from the industry, but she struggled with the physical and emotional toll of being on stage. She gave a candid interview to Variety in June 2023 about the challenges she faces as an actress with MS, expressing uncertainty about her future in the entertainment industry. Despite undergoing multiple hospitalizations and facing mobility issues, Applegate remains determined to continue fighting and advocating for herself.
In November 2022, Applegate shared her physical symptoms and struggles with seeking medical attention before her MS diagnosis. She expressed anger and frustration about her deteriorating health and the impact it had on her life and career. At her Hollywood Walk of Fame ceremony, she chose to go barefoot due to the discomfort caused by her MS symptoms. Applegate has used her platform to raise awareness about MS, incorporating humor as a coping mechanism to navigate the challenges she faces. Overall, she remains determined to find joy and purpose despite the hardships brought on by her diagnosis.
