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You’ve waited all season long and now it’s the beginning of March Madness.

Louisville will tip off against Creighton at 12:15 p.m. ET as a slight 2.5-point favorite at Caesars Sportsbook.

Both teams are coming off losses in their respective conference championship games, with the Bluejays losing to St. Johns in the Big East final, while Louisville lost to Duke in the ACC Tournament.

After two days of First Four games we now get to wager on real NCAA Tournament contests, plus we have an exclusive sign-up offer from our friends at Caesars Sportsbook.

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Creighton vs. Louisville prediction

Louisville had won 11 straight games before running into the Duke buzzsaw in the ACC final.

Are they just a better team than Creighton?

Betting on College Basketball?

KenPom certainly thinks so.

According to the college basketball statistics site, the Cardinals are rated No. 23 in the country, while the Bluejays are a bit further down, coming in at No. 36.

Creighton does have a better effective field goal rate (55.8 percent), good for 28th in the nation, slightly higher than Louisville’s No. 82 ranking (53.4 percent).

The Bluejays also have a slightly better opponent field goal percentage (48th best in the country), coming in at 41.21 percent, while the Cardinals allow teams to shoot 42.48 percent (97th).

Still, the advanced stats favor Louisville despite the surface level data pointing towards Creighton.

For me, this game comes down to guard play and Louisville senior guards Chucky Hepburn and Terrence Edwards Jr. are too dangerous to ignore.

Target the favorite against the spread in this No. 8 vs. No. 9 matchup.

PICK: Louisville -2.5 (-110, Caesars Sportsbook)

Think the underdog is the better bet? Go ahead and fade this pick.

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Why Trust New York Post Betting

Erich Richter is a brazilian jiu-jitsu blue belt but he has a black belt in MMA betting. During the football season he’s showcased massive profits at The Post in the player prop market the last two seasons. While constantly betting long shots, his return on investment is 30.15 percent since 2022.

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