Researchers at Wayne State University have reported new findings linking exposure to per- and polyfluorinated alkyl substances (PFAS) in males to health issues in their offspring. The study, published in Environment International, examined the impact of PFAS mixtures on sperm methylation and transcriptome changes in offspring metabolic tissues like the liver and fat. PFAS chemicals are known to be associated with chronic diseases, inflammation, and immune system effects, making this research on reproductive outcomes, fertility, and offspring metabolism particularly relevant.
Dr. Michael C. Petriello, Assistant Professor in the Institute of Environmental Health Sciences, emphasized the importance of PFAS research, particularly in Michigan where the EPA is beginning to regulate these chemicals under the Clean Water Act. The study found that exposure of fathers to PFAS can impact the health of their offspring, a novel finding in the field. Previous research by Dr. Petriello on cardio-metabolic health effects of PFAS exposure complements the current study, which focuses on how paternal exposures can influence the next generation through sperm-related markers.
Dr. J. Richard Pilsner, Professor of Obstetrics and Gynecology, highlighted the traditional emphasis on maternal health during pregnancy for offspring health, but stressed the importance of environmental factors prior to conception as well. The team’s results showed that exposure to a combination of legacy and emerging PFAS chemicals in male mice led to abnormal sperm methylation and altered gene expression in offspring liver and fat tissues in a sex-specific manner. This indicates that preconception PFAS exposure in males can impact the phenotype of the next generation.
The research findings may have significant implications for understanding how harmful chemicals in communities can impact future generations, as well as how medical professionals advise patients. Dr. Pilsner hopes that the study will increase awareness of the importance of male health in influencing offspring development. Empowering individuals with information about the impact of pre-conception health on their children’s well-being could lead to positive changes in future generations.
Wayne State University’s Vice President for Research, Dr. Ezemenari M. Obasi, highlighted the importance of this cutting-edge research in improving public health outcomes. The university’s researchers are at the forefront of investigating new methods to enhance well-being locally, nationally, and globally. By exploring innovative solutions and empowering communities with knowledge about harmful chemicals, Wayne State is playing a key role in promoting health and well-being for all. This study exemplifies the university’s commitment to generating impactful research that benefits society.