Cafestol, a natural compound found in unfiltered coffee, is believed to have potential benefits for metabolic health. Recent research has suggested that consuming 6 milligrams of cafestol twice daily for 12 weeks may lead to slight weight and body fat loss, although it did not significantly improve insulin sensitivity or glucose tolerance. While more research is needed, experts believe that in moderation, consuming unfiltered coffee could offer health benefits due to the presence of cafestol.
Studies have shown that cafestol is a diterpene compound found in coffee brewed through unfiltered methods such as boiled, Turkish, French press, and espresso coffee. It is responsible for enhancing coffee’s flavor and aroma and has been linked to potential health benefits. Some research indicates that cafestol may help prevent type 2 diabetes by increasing insulin secretion, enhancing glucose uptake, and improving insulin sensitivity, as observed in cell studies and mouse models.
A double-blinded randomized controlled trial was conducted to assess the impact of 6 milligrams of cafestol twice daily for 12 weeks on insulin sensitivity and glucose tolerance in healthy individuals with high waist circumference. The results indicated that while cafestol led to slight weight and body fat loss, it did not significantly improve insulin sensitivity or glucose tolerance in the study participants. Despite these mixed results, some positive effects were noted, such as reductions in weight, visceral fat, and liver enzyme levels.
Experts suggest that these findings may help explain the associations between coffee consumption and a reduced risk of type 2 diabetes. They also underscore the need for further research on the potential benefits and drawbacks of cafestol on metabolic health. While cafestol appears to aid in weight loss and fat reduction, concerns have been raised about its potential to increase insulin resistance, which could raise the risk of developing type 2 diabetes. Recommendations include consuming organic and unfiltered coffee, avoiding sugary or high-fat additives, and incorporating coffee as part of a balanced lifestyle.
The study participants were monitored throughout the trial with various assessments, including blood samples, mixed-meal testing, MRI scans, and insulin tests. Some individuals experienced side effects such as gas, nausea, loose stools, and headaches, although no harmful changes to liver or kidney function were reported. Researchers believe that higher doses or longer interventions with cafestol may provide more clarity on its role in diabetes prevention and metabolic health.
In conclusion, while the research on cafestol’s effects on metabolic health is ongoing, moderate coffee consumption of 2 to 3 cups per day has been associated with cardiometabolic benefits. Recommendations for optimizing the potential benefits of coffee consumption include choosing organic and unfiltered options, avoiding sugar and high-fat add-ons, consuming coffee in the morning or early afternoon, and grinding coffee beans at home for freshness. Further studies are needed to fully assess the impact of cafestol on metabolic health and its potential role in preventing type 2 diabetes.
